Correlation of MMP-9 and nm23-H1 Expression with Invasion and Metastasis in Gallbladder Carcinoma

Objective To dectect the expression of MMP-9 and nm23- H1 in gallbladder carcinoma and to explore their correlation with invasion and metastasis of gallbladder carcinoma. Methods The expression of MMP-9 and nm23- H1was detected by immunohistochemistry(PV-9000) in 44 samples with invasion and metastasis and 16 samples without invasion and metastasis. Results In invasion and metastasis samples,the positive rates of MMP-9 and nm23-H1 were 72.7%(32/44)and 27.3%(12/44) respectively.In samples without invasion and metastasis,the positive rates were 37.5%(6/16) and 68.8%(11/16),respectively.The expression of MMP-9 was positively related to invasion and metastasis of gallbladder carcinoma(P0.05),but negatively related to nm23-H1 expression(P 0.01). The expression of nm23- H1 was negatively related to invasion and metastasis of gallbladder carcinoma(P0.01). Conclusion MMP-9 and nm23-H1 may be useful diagnostic parameters for invasion and metastasis of gallbladder carcinoma.