Advancement of Heparanase in Gastrointestinal Tumor
Ji W
Abstract
Ji W
Abstract
Objective: To sum up the structure and the function of heparanase, and correlations with gastrointestinal tumorigenesis and metastasis and their possible mechanism. Methods: Consulting related literatures home and abroad. Results and conclusion: Heparanase is the key enzyme to degrade extracellular matrix and closely related to tumor cell invasion and metastasis,become a novel cancer therapy target in gastrointestinal tumor.
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Objective: To sum up the structure and the function of heparanase, and correlations with gastrointestinal tumorigenesis and metastasis and their possible mechanism. Methods: Consulting related literatures home and abroad. Results and conclusion: Heparanase is the key enzyme to degrade extracellular matrix and closely related to tumor cell invasion and metastasis,become a novel cancer therapy target in gastrointestinal tumor.
Key concepts: Heparanase, Medicine, Metastasis, Extracellular matrix, Carcinogenesis, Cancer, Mechanism (biology), Cancer research