Changes of Serum Resistin and High-Sensitivity C-Reactive Protein in Patients with Obesity and Type 2 Diabetes Mellitus

Objective To study serum resistin and high-sensitivity C-reactive protein(hs-CRP) level,and their relationship with insulin resistance in patients with obesity and type 2 diabetes mellitus.Methods The subjects were divided into 3 groups: the normal group(NC),28 cases;the type 2 diabetes group with normal weight(DM1),30 cases;and the obese group with diabetes(DM2),30 cases.The serum resistin was measured by enzyme immunoassay and hs-CRP was detected by unoturbidimetry.Homeostasis model assessment β-cell index(HOMA2-%B),insulin resistance index(HOMA2-IR),and insulin sensitivity index(HOMA2-%S) were calculated.Results The serum resistin and hs-CRP levels in the DM1 group were higher than those in the NC group(P0.05);the levels in the DM2 were higher than those in either the NC group or the DM1 group(P0.01).Pearson analysis showed that the serum resistin was correlated with BMI,hs-CRP,HOMA2-%B,and HOMA2-IR(r=-0.252,0.563,0.225,0.667,respectively,P0.05 for all),and that hs-CRP was correlated with WC,BMI,HOMA2-IR(r=0.773,0.594,0.662,respectively,P0.01 for all),and resistin(r=0.563,P0.05).After adjusting age and plasma glucose,hs-CRP was still associated with WC,BMI,HOMA2-IR,and resistin.Conclusion The increase of serum resistin level in patients with obesity and type 2 diabetes and its correlation with BMI,HOMA2-%B,HOMA2-%IR,and hs-CRP suggest that resistin may serve as an important link between obesity and insulin resistance.Resistin and hs-CRP play an important role in patients with obesity and diabetes