The Research on Acute and Long Time Toxicity of Angelicaroot Capsule

ve: To evaluate acute and long-time toxicity of angelicaroot capsule and provide the toxicology basis for safety using in clinical. Method: Mice of Kun Ming species were selected in acute toxicity experiment by mouth and Wistar rats and hybrid dogs were selected in 90 days long time toxicity experiment by mouth. Result: Mice and rats appeared tip cyanosis, agitated activity, quicken respiration after 10 minutes oftaking angelicaroot capsule. Several mice died because of failure of respiration. But toxicity symptoms of rats disappear after 30 days of taking angelicaroot capsule. The rats in higher dose angelicaroot capsule group grew slower than the rats in control group. It can be seen of gaseous distention in stomach, edema of mucous membrane in pathology inspection. In higher dose group, there were myeline bodies in liver cells of some rats and dogs, but it is reversible. There were not different between all angelicaroot capsule groups and control group in blood and biochemistry indexes of rats and dogs. LD50 of mice by mouth is 7.35±0.62 g·kg-1. Conclusion: Angelicaroot capsule belongs to lower class toxicity drug.