The value of high-sensitivity C-reactive protein in patients with coronary heart disease

Objective To study the variation of serum high-sensitivity C-reactive protein (hs-CRP) level in patients with the different types of coronary heart disease (CHD), and to evaluate the value of hs-CRP in the clinical diagnosis of CHD. Methods HITACHI 7180 automatic biochemitry analyzer was applied to measuring the serum hs-CRP level, and HP2500 type color Doppler ultrasound analyzer applied measuring the intima-media thickness (IMT) of carotid artery for all subjects. The results were analyzed with statistical methods, including t test and multiple factor Logistic regression analysis.Results The serum level of hs-CRP and IMT were significantly higher in CHD group than those of control group (5.64±1.83 vs 0.89±0.51 mg/L,P0.01;1.62±0.35 vs 0.83±0.21 mm,P0.01 respectively), and the serum level of hs-CRP was positively correlative to that of IMT (r=0.627 8,P0.01); the serum hs-CRP level was elevated step by step following the stable angina pectoris (SAP), the unstable angina pectoris (UAP) to the acute myocardial infarction (AMI), and the serum hs-CRP level was significantly higher in AMI group and UAP group than that of SAP group; the serum hs-CRP might be a new and important risk factor for carotid atherosclerosis during the development of CHD.Conclusion hs-CRP is one of the risk factors for coronary heart disease; the serum hs-CRP level is related with the different types of CHD, which suggests that measurement of hs-CRP contributes to diagnosis and prognosis evaluation of CHD.