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The Effects of Calcitonin Gene Related Peptide on the Expression of P53 Protein during Focal Cerebral Ischemia/Reperfusion in Rats

Zheng Guang-shun

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Abstract

Objective To study the effects of calcitonin gene related peptide(CGRP) on the expression of P53 protein in brain tissue of rats with focal cerebral ischemia/reperfusion(I/R),and to explore the protective effects and mechanism of CGRP on ischemia brain tissue. Methods Using middle cerebral artery occlusion (MCAO) to make focal cerebral ischemia model, the expression of P53 protein was detected with immunohistochemical method and analyzed by microimage analysis system. Results P53 protein positive cells in hippocampus and parietal lobe of rats were not found in sham group, but were found a lot in focal cerebral I/R group.The average gray values of P53 protein positive cells in hippocampus and parietal lobe were higher in CGRP group than in I/R group(P0.01). Conclusion Downregulation of CGRP on the expression of P53 protein in ischemic neurons might promote the recovery of the ischemia neurons.

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Objective To study the effects of calcitonin gene related peptide(CGRP) on the expression of P53 protein in brain tissue of rats with focal cerebral ischemia/reperfusion(I/R),and to explore the protective effects and mechanism of CGRP on ischemia brain tissue. Methods Using middle cerebral artery occlusion (MCAO) to make focal cerebral ischemia model, the expression of P53 protein was detected with immunohistochemical method and analyzed by microimage analysis system. Results P53 protein positive cells in hippocampus and parietal lobe of rats were not found in sham group, but were found a lot in focal cerebral I/R group.The average gray values of P53 protein positive cells in hippocampus and parietal lobe were higher in CGRP group than in I/R group(P0.01). Conclusion Downregulation of CGRP on the expression of P53 protein in ischemic neurons might promote the recovery of the ischemia neurons.

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Available abstract

Objective To study the effects of calcitonin gene related peptide(CGRP) on the expression of P53 protein in brain tissue of rats with focal cerebral ischemia/reperfusion(I/R),and to explore the protective effects and mechanism of CGRP on ischemia brain tissue. Methods Using middle cerebral artery occlusion (MCAO) to make focal cerebral ischemia model, the expression of P53 protein was detected with immunohistochemical method and analyzed by microimage analysis system. Results P53 protein positive cells in hippocampus and parietal lobe of rats were not found in sham group, but were found a lot in focal cerebral I/R group.The average gray values of P53 protein positive cells in hippocampus and parietal lobe were higher in CGRP group than in I/R group(P0.01). Conclusion Downregulation of CGRP on the expression of P53 protein in ischemic neurons might promote the recovery of the ischemia neurons.

Key concepts: Calcitonin gene-related peptide, Ischemia, Calcitonin, Hippocampus, Middle cerebral artery, Medicine, Immunohistochemistry, Internal medicine

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