Effects of Qingbai capsule on hemorheological changes and formation of extracorporeal thrombus in rats with acute blood stasis

Objective: To investigate the effects of Qingbai capsule(QBC) on hemorheological changes and extracorporeal thrombus formation in a rat model of acute blood stasis.Methods: The acute blood stasis was induced by subcutaneous injection of large dose of adrenaline hydrochloride and ice-water socking in rats.Rats were treated with oral QBC daily for 14 d.Then, the hemorheological parameters and extracorporeal thrombus formation were observed for evaluating the effects of QBC.Results: QBC(6.0,3.0 and 1.5 g·kg-1) obviously decreased the whole blood viscosity at 200,30,5 and 1 s-1 shear rate and the relative viscosity at 200 and 1 s-1 shear rate.QBC significantly reduced the plasma viscosity,the hematocrit(HCT), the content of fibrinogen(FIB) and the platelet adhesiveness;also obviously shortened the length,wet and dry weights of thrombus(P0.05 and 0.01,as compared with vehicle).Conclusion: QBC effectively ameliorates the hemorheological changes,and inhibits platelet adhesion and thrombus formation.