Clinical application for improving differential diagnosis of benign vs.malignancy of hepatic tumor by contrast sonography

Objective To approach the application value in improving early noninvasive differential diagnosis of liver benign or malignant tumor by contrast-enhanced ultrasound with SonoVue compared with conventional ultrasound.Methods 78 cases were found with focal liver lesion(FLL) by conventional ultrasound through retrospective analysis.Contrast-enhanced ultrasound was further applied after initial diagnosis of benign or malignant tumor was given according to the feature of two-dimensional and color Doppler ultrasound combined with history.The contrast media perfusion process in the lesion was analyzed and corrected judgement was given.Finally statistical analysis was done with pathological results as the gold standard.Results The pathological result showed there were 32 cases with benign lesions and 46 cases with malignant lesions in 78 lesions.Contrast-enhanced ultrasound in the differential diagnosis of benign or malignant lesions was obviously better than conventional ultrasound with the sensibility of 92.8% and the specificity of 91.7%.Conclusion Real-time gray scale contrast-enhanced ultrasound through intravenous bolus injection with SonoVue is helpful to early noninvasive differential diagnosis of liver benign or malignant local lesions.