Relationship Between Serum Endothelial Lipase and Macrovascular Complications in Type 2 Diabetes

Aim To explore the relationship of serum endothelial lipase and macrovascular complications in type 2 diabetes patients(T2DM).Methods 66 patients with type 2 diabetes were divided into macrovascular complications group and no macrovascular complications group.30 cases of healthy persons were used as control group.Fasting serum endothelial lipase levels were measured with enzyme linked immunosorbent assay(ELISA) and compared between groups.Results The serum endothelial lipase in type 2 diabetes with macrovascular complications(3.31±1.30 ng/L) was significantly higher than that of no macrovascular complications group(2.54±1.11 ng/L) and control group(2.36±0.91 ng/L,P0.05).No macrovascular complications group had no significant differences from the control group.Related analysis showed that the serum endothelial lipase in type 2 diabetes was positively correlated with glycosylated hemoglobinA1c(HbA1c) and high sensitive C-reactive protein(hs-CRP),and negatively correlated with high-density lipoprotein(HDL).Conclusions Endothelial lipase might be involved in the occurrence and development of macrovascular lesions in type 2 diabetes patients.