Influence of resveratrol on the proliferation and cell cycle of human kidney cancer cells

Objective To investigate the influence of resveratrol(Res) on the proliferation and cell cycle of 786-0 human kidney cancer cells.Methods The Res of 12.5,25,50,100 μmol/L were used to treat kidney cancer cells for 24 h;blank control group was set.The cell cycle phase distribution of kidney cancer cells were analyzed by using flow cytometry.Results Res of all concentrations inhibited the proliferation of kidney cancer cells,the ratio of cells in G1/G2 phase were decreased conspicuously and the S phase were apparently increased,the difference has statistics significance compared with the control group(P0.05).The Res groups compared with each other,the 12.5 μmol /L group with 25 μmol/L group,50 μmol/L group,100 μmol/L group had significant difference(P0.05);but the 25 μmol/L group and 50 μmol/L group,100 μmol/L group had no significant difference(P0.05).Conclusions Human renal cancer cells can be inhibited in a dose-dependent by Res,and it can be visibly inhibited by the 12.5 μmol/L of Res.The inhibitory affect on human renal carcinoma cells proliferation reach peak when the concentration of Res hits 25 μmol/L,and it cannot be improved when continue to rise the concentration of Res.