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Expression and significance of FUT1,FUT4 and LeY in endometrial carcinoma

Yan Deng

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Abstract

Objective:To study the expression and significance of FUT1,FUT4 and LeY in normal endometrium,atypical hyperplasia of endometrium and endometrial carcinoma.Methods:The expression levels of LeY,FUT1 and FUT4 in adenocarcinoma of endometrium, atypical hyperplasia of endometrium,simple hyperplasia,complex hyperplasia and normal endometrium during proliferative phase were detected by immunohistochemistry.Results:FUT1,FUT4 and LeY didnt express in normal endometrium,and overexpressed in simple hyperplasia,complex hyperplasia,adenocarcinoma of endometrium and atypical hyperplasia of endometrium,which were located in cytomembrane and/or cytoplasm of glandular epithelial cells.Overexpression of LeY in endometrial carcinoma was related to histological grades,not clinical surgical-pathological staging.Conclusion:FUT1,FUT4 and LeY play an important role in oncogenesis and development of endometrial carcinoma,which may participate in early lesions of endometrial carcinoma.

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Objective:To study the expression and significance of FUT1,FUT4 and LeY in normal endometrium,atypical hyperplasia of endometrium and endometrial carcinoma.Methods:The expression levels of LeY,FUT1 and FUT4 in adenocarcinoma of endometrium, atypical hyperplasia of endometrium,simple hyperplasia,complex hyperplasia and normal endometrium during proliferative phase were detected by immunohistochemistry.Results:FUT1,FUT4 and LeY didnt express in normal endometrium,and overexpressed in simple hyperplasia,complex hyperplasia,adenocarcinoma of endometrium and atypical hyperplasia of endometrium,which were located in cytomembrane and/or cytoplasm of glandular epithelial cells.Overexpression of LeY in endometrial carcinoma was related to histological grades,not clinical surgical-pathological staging.Conclusion:FUT1,FUT4 and LeY play an important role in oncogenesis and development of endometrial carcinoma,which may participate in early lesions of endometrial carcinoma.

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Available abstract

Objective:To study the expression and significance of FUT1,FUT4 and LeY in normal endometrium,atypical hyperplasia of endometrium and endometrial carcinoma.Methods:The expression levels of LeY,FUT1 and FUT4 in adenocarcinoma of endometrium, atypical hyperplasia of endometrium,simple hyperplasia,complex hyperplasia and normal endometrium during proliferative phase were detected by immunohistochemistry.Results:FUT1,FUT4 and LeY didnt express in normal endometrium,and overexpressed in simple hyperplasia,complex hyperplasia,adenocarcinoma of endometrium and atypical hyperplasia of endometrium,which were located in cytomembrane and/or cytoplasm of glandular epithelial cells.Overexpression of LeY in endometrial carcinoma was related to histological grades,not clinical surgical-pathological staging.Conclusion:FUT1,FUT4 and LeY play an important role in oncogenesis and development of endometrial carcinoma,which may participate in early lesions of endometrial carcinoma.

Key concepts: Endometrium, Atypical hyperplasia, Hyperplasia, Carcinoma, Endometrial hyperplasia, Adenocarcinoma, Medicine, Pathological

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Expression and significance of FUT1,FUT4 and LeY in endometrial carcinoma — Research Paper | ScholarLens