Pregnancy Outcomes of Different in Vitro Fertilization Methods in Older Patients IVF-ET Cycles with Poor Ovarian Response

Objective: To compare the efficacy of conventional in vitro fertilization(IVF) and intracytoplasmic sperm injection(ICSI) in older patients with poor ovarian response. Methods: The data of 381 in vitro fertilization-embryo transfer(IVF-ET) cycles of older patients(≥40 years old) with poor ovarian response were analyzed retrospectively. Those cycles were divided into two groups:IVF group(conventional IVF,200 cycles) and ICSI group(181 cycles). Fertilization rate and clinical pregnancy rate were compared between two groups. Results: The fertilization rate and clinical pregnancy rate in the IVF group were insignificantly higher than those in the ICSI group,while the rate of effective cycles and high quality embryos in the ICSI group were very limitedly higher than those in the IVF group. However, there were not statistically differences in those rats between two groups(P0.05). Conclusions: ICSI treatment did not increase fertilization rate and clinical pregnancy rate in IVF-ET cycles in those patients at ≥40 years with poor ovaian response.