Clinic study of therapeutic effect of chronic hepatitis B patients treated with interferon α

Objective To study the therapeutic effect of α-2b interferon(IFN-α-2b) treating chronic hepatitis B(CHB).Methods One hundred and forty CHB cases were divided into 2 groups: 83 cases in IFN-α-2b treatment group,and 40 cases in liver-protective group.The liver function,change of hepatitis B virus marker and side-effects of α-2b interferon were observed. Results In the treatment group,the complete response rate,the ALT recovery rate,HBeAg negative rate and HBV-DNA negative rate were significantly higher than those in liver-protective group at the end of the treatment. In the treatment group,better therapeutic effect revealed in higher ALT Level and HBV-DNA≤106 copies/mL before treatment.The therapeutic effect might correlate with gender and age.The side-effects of IFN-α-2b could recover quickly without special treatment.Conclusion IFN-α-2b may inhibit the replication of HBV,improve liver functions,and speed the spontaneous seroconvesrsion of HBeAg and HBV-DNA,and is one of the effective and safety medicines for treating CHB.