Expression of Ki-67 and p27 in transitional cell carcinorma of bladder

Objective: To study the expression of p27 and Ki-67 in transitional cell carcinorma of bladder (TCC) and evaluate the correlation between expression of p27 and Ki-67 and tumor cell proliferation. Methods: With mouse anti-human p27 and Ki-67 monoclonal antibody, immunohistochemistry was performed to examine the expression of p27 and Ki-67 in 79 cases of TCC, and 30 cases of nomal paracarcinoma as control. Results: Both lower expression of p27 and overexpression of Ki-67 were detected in TCC; p27 expression in TCC was negatively correlated with the Ki-67 labeling index (Ki-67 LI), the tumor pathological grade, clincal stage and lymphoid node metastasis. Conclusions: p27 expression and Ki-67 LI reflect the ability of tumor growth and invasion at the basis of angiogenesis and proliferation respectively. Combined examination of p27 and Ki-67 LI is of great importance in evaluating the biological behavior of TCC and its prognosis.