The efficacy and safety of atorvastatin in treatment of combined dyslipidemia

Objective To evaluate the efficacy and safety of atorvastatin manufactured by Honghui Medicine Development Co.in hyperlipidemia,especially in combined dyslipidemia.Methods 105 cases with combined dyslipidemia were divided into 2 groups at random.Atorvastatin 10 mg/d was given to 52 cases in one group and simvastatin (Zocor manufactureed by MSD) also 10 mg/d was given to 53 cases in another group.The efficacy and adverse reactions were recorded.Results Eight weeks later,in atorvastatin group,TC,LDL C,TG and (TC HDL C)/HDL C were significantly lowered by 30%,40%,30% and 36% respectively (P 0.01). The increase in HDL C(5%) was not statistically significant (P0.05).The atorvastatin was significantly superior to simvastatin in reduction of LDL C and TG (P0.05),and was similar in reduction of TC.The adverse reactions were mild and relatively rare in both groups.Conclusions Atorvastatin 10 mg/d can significantly lower TC,LDL C,TG and (TC HDL C)/HDL C in combined dyslipidemia.Atorvastatin is superior to simvastatin in lowering LDL C and TG.The adverse reactions of atorvastatin are mild and can be well tolerated.