Study on the correlations between ICAM-1 and IL-6 in patients with coronary heart disease

Objective To explore the difference of interleukin-6(IL-6) and intercellular adhesion molecule-1(ICAM-1)in different sub-type of coronary heart disease(CHD) and the relationship between IL-6,ICAM-1 and CHD.Methods A total of 200 patients were divided into three groups:acute coronary syndrome group(n=80),stable effort angina group(n=50),control group(n=30).The levels of IL-6 and ICAM-1 were detected by ELISA.Then the correlation between ICAM-1 and IL-6 were analyzed.Results(1)The serum levels of IL-6 and ICAM-1 in ACS group were significantly higher than those in SAP and control groups(P0.05).But there was no significant difference between SA group and the control group(P0.05).(2) Correlation analysis suggested the levels of IL-6 were positively correlated with ICAM-1(P0.05).Conclusion The levels of IL-6 and ICAM-1 are important indexes for the diagnosis of CHD and the severity of CHD.