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HPLC-ELSD determination of ginsenoside Rg1 in Danbie capsules

Jinbao Cai

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Abstract

Objective To develop an HPLC method for the content determination of ginsenoside Rg 1 in Danbie capsules.Methods A Purospher STAR RP-18e column(250 mm×4.6 mm,5μm) was adopted with acetonitrile-water gradient elution.The drift-tube temperature of ELSD was 10℃,the flow rate of N2 was 1.9 L/min.Results The linear range was 2-10μg(r=0.999 5).The average recovery was 99.5%,RSD was1.63%.Conclusion The method is reliable,reproducible and high precision.It can be used for the determination of ginsenoside Rg1 in Danbie capsules.

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What this paper is about

Objective To develop an HPLC method for the content determination of ginsenoside Rg 1 in Danbie capsules.Methods A Purospher STAR RP-18e column(250 mm×4.6 mm,5μm) was adopted with acetonitrile-water gradient elution.The drift-tube temperature of ELSD was 10℃,the flow rate of N2 was 1.9 L/min.Results The linear range was 2-10μg(r=0.999 5).The average recovery was 99.5%,RSD was1.63%.Conclusion The method is reliable,reproducible and high precision.It can be used for the determination of ginsenoside Rg1 in Danbie capsules.

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Available abstract

Objective To develop an HPLC method for the content determination of ginsenoside Rg 1 in Danbie capsules.Methods A Purospher STAR RP-18e column(250 mm×4.6 mm,5μm) was adopted with acetonitrile-water gradient elution.The drift-tube temperature of ELSD was 10℃,the flow rate of N2 was 1.9 L/min.Results The linear range was 2-10μg(r=0.999 5).The average recovery was 99.5%,RSD was1.63%.Conclusion The method is reliable,reproducible and high precision.It can be used for the determination of ginsenoside Rg1 in Danbie capsules.

Key concepts: Ginsenoside Rg1, Chromatography, Medicine, Chromatography detector, High-performance liquid chromatography, Drift tube, Gradient elution, Ginsenoside

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