Observation on the effectiveness of immunization with Hepatitis B vaccine in 307 workers in Maoming City.

Objective To evaluate the immune effect of homemade recombinant hepatitis B vaccine in adolescents aged 20 to 40 years Methods Detection of Hepatitis B virus antigen and antibody was performed using ELISA and RIA methods in 307 HBV test negative medical school students According to 0,1and 6-month immunization program,each subject was injected with 5μg/0 5ml of recombinant hepatitis B vaccine produced in China each time Results After complete immunization,the protective efficacy was 90 88%(279/307) Among those who had higher anti-HBs titre,females were significantly more than males (P0 05) Conclusions The protective efficacy of yeast -derived recombinant hepatitis B vaccine produced in China reaches 90 88% and the titer of anti -HBs at the ninth month are enhanced with the frequency and time of vaccination