A Follow-up on Efficacy of Immunization of Yeast-derived Recombinant Hepatitis B Vaccine after 11 Years

[Objective]To evaluate the immune efficacy after 11 years' Immunization of domestic yeast-derived recombinant hepatitis B vaccine in newborns. [Methods]A follow-up on children who were born in 1997 and vaccinated with domestic yeast-derived recombinant hepatitis B vaccine at their birth was implemented to test the HBsAg,anti-HBs and anti-HBc.The incidence of acute hepatitis B among subjects with hepatitis B vaccinated was monitored since 1998. [Results]The positive rate of HBsAg was 0.54%,compared with that before vaccination in the same area,the positive rate of HBsAg showed a substantially decrease,the vaccine protective efficacy was 88.05%(95% confidence intervals 85.17%~91.17%).Acute hepatitis B was not found in children immunized with yeast-derived recombinant hepatitis B vaccine. [Conclusion]The domestic yeast recombinant hepatitis B vaccine has a long-term protective effect,and a booster dose is not necessary currently.