Observation on Serological Immune Effect of Four Recombinant Yeast Hepatitis B Vaccines

[Objective]In order to study the immune effects of different doses and types of genetic engineering hepatitis B vaccines made in China in elder children and adults,Provide scientific basis for making Hepatitis B immunization strategies.[Methods]Four types of hepatitis B vaccines was given to primary,junior high school students and adults with negative of HBsAg,anti-HBs and anti-HBc based on 0,1,6 immunization program.One month later of the full immunization,anti-HBs of hepatitis B in the serum was tested with RIA.[Results]One month after reinforce immunization,anti-HBs positive conversion rate of 106 primary and middle school students with 5 μg /agent(A vaccine) was 99.06% and 127 students given 10 μg/agent of beer yeast vaccine(B vaccine) was 95.28%.83 students who accepted 10 μg/agent of Hanxun yeast(C vaccine) was 98.80% and another 118 students with Chinese hamster ovary cells of hepatitis B vaccine(D vaccine) was 100.0%.211 adults with D vaccine was 93.37%.One month after inoculation of A,B,C,D vaccine,GMT were 1∶472.59,1∶773.24,1∶575.87,1∶613.71 respectively(P0.05).GMT in adults with the same vaccine was higher than that in children(P0.01).[Conclusion]The serum antibody protective rate and GMT in children and adults with different types of vaccines were high.The immune effect of adults group with 10 μg/agent Hanxun was better than that in children.