Relationship between serum level of MCP-1 and insulin resistance in elderly patients with hypertension.

Objective To investigate the relationship between serum level of MCP1 and insulin resistance in elderly patients with hypertension.Methods 60 cases of elderly patients with hypertension were divided into hypertension group(n=29)and hypertension with insulin resistance group(n=31)according to insulin resistance index,and 20 healthy individuals were selected as the control goups.Serum insulin was measured by radioimmunoassay,to evaluate insulin resistance and islet βcell function index by homeostasis model assessment method,and serum level of MCP-1 was measured by Elisa method.Results The serum level of MCP-1 in hypertension group was higher than that in control group(P0.05).The levels of serum insulin,MCP-1、HOMA-IR、HOMA-islet in hypertension with insulin resistance group were higher than those in hypertension group and control group(P0.05).Dependability analysis showed serum level of MCP-1 had positive correlation to levels of FPG、TC、LDL-C、serum insulin、HOMA-IR、HOMA-islet.Conclusion The levels of serum insulin and MCP-1,HOMA-IR、HOMA-islet were higher than those in hypertension group and control group.Presenting hyperinsulinemia,compensative function enhancement of βcell of islet.The serum level of MCP-1 had positive correlation to levels of FPG、TC、LDL-C、serum insulin、HOMA-IR、HOMA-islet.