Influence of Phlegm and Blood Stasis Syndrome on Levels of hs-CRP,TNF-α,IL-4,IL-6 and ICAM-1 of Pre-Hypertension Patients

Objective:To study the effect of phlegm and blood stasis syndrome on the levels of hs-CRP,TNF-α,IL-4,IL-6 and ICAM-1 in patients with pre-hypertension.Methods:133 cases were included in the first diagnosis of pre-hypertension and according to the TCM syndrome types were divided into phlegm and blood stasis syndrome(69 cases) and no phlegm and blood stasis syndrome(64 cases).30 cases with ideal blood pressure were included as control group at the same time.The levels of serum hs-CRP,TNF-α,IL-4,IL-6 and ICAM-1 were determined and the relationship between above-mentioned indexes and pre-hypertension was observed.We discussed the influence of phlegm and blood stasis syndrome on the inflammatory reaction of patients with pre-hypertension.Results:(1) Compared with control group,the levels of hs-CRP,IL-4,IL-6 and ICAM-1of pre-hypertension group were significantly increased(P 0.01).(2) Compared with no phlegm and blood stasis group,the levels of hs-CRP,TNF-α,IL-4 and ICAM-1 of phlegm and blood stasis group were significantly increased(P 0.01).Conclusion:(1)As the early stages of hypertension,pre-hypertension has inflammatory damage,suggesting that inflammatory damage runs through the whole process of the occurrence and development of hypertension.It is an important part of hypertension development.(2)The levels of inflammatory factor and hs-CRP of phlegm and blood stasis group were significantly increased,suggesting that the inflammation of phlegm and blood stasis group is more obvious than no phlegm and blood stasis group and providing objective basis for TCM syndrome differentiation of pre-hypertension and research direction of early TCM intervention to hypertension.