Study on relationship between phlegm stasis syndrom differentiation and corresponding inflammatory markers of coronary heart disease

Objective:To explore the relationship between syndrome differentiation of phlegm and blood stasis of coronary heart disease and the levels of high-sensitivity C-reactive protein(hs-CRP)and soluble CD40 ligand(sCD40L).Methods:Sixty patients with coronary heart disease were evenly divided into three groups randomly:the non-phlegm and non-stasis group(n=20),the congealing phlegm of heart vessels group(n=20)and the intermingled phlegm and blood stasis group(n=20).Twenty healthy volunteers was as the control group(n=20).The level of hs-CRP was detected with immunity transmission turbidity.The levels of sCD40L was determined by ELISA.Observe the differences within groups.Results:The levels of serum hs-CRP and sCD40L showed higher in the non-phlegm and non-stasis group,the congealing phlegm of heart vessels group and the intermingled phlegm and blood stasis group than those of the control group(P0.05 or P0.01).Compared with the non-phlegm and non-stasis group,patients in the congealing phlegm of heart vessels group and the intermingled phlegm and blood stasis group have higher levels of hs-CRP(P0.05 or P0.01),and there was statistics significance between the two groups(P0.01).It showed the level of serum hs-CRP was related with syndrom differentiation of phlegm and blood stasis in coronary heart disease patients.Conclusions:Syndrom differentiation of phlegm and blood stasis in coronary heart disease may be according to the level of serum hs-CRP.