ffects of Fluoxetine and Tianeptine on Expression of Bcl-2 in Hippocampus of Chronic Stress Depression Rats

Objective To research the effects of fluoxetine and tianeptine on expression of Bcl-2 in hippocampus of chronic stress depression rats.Methods All the experimental rats were divided by random into 4 groups:Group of control,Group of depression,Group of fluoxetine and Group of tianeptine.The rats of Group of depression,Group of fluoxetine and Group of tianeptine were applied stress for 21 days,and meanwhile Group of control no stress.The rats of Group of fluoxetine were fed with fluoxetine,Group of tianeptine were fed with tianeptine,while another groups were fed with normal sodium.The expression of Bcl-2 was detected by Western-blotting method.Results In Western-blotting method,the level of Bcl-2 in the hippocampus of Group of depression is less than that of Group of control(P 0.01);that of Group of fluoxetine is more than that of Group of depression(P 0.01) and no obvious difference with Group of control(P 0.05);that of Group of tianeptine is more than that of Group of depression(P 0.01) and less than Group of control but no obvious difference(P 0.05).Conclusion The expression of Bcl-2 in hippocampus of chronic stress depression rats decreased and could be reversed by fluoxetine and tianeptine.