Clinical observation of high-dose Atorvastatin in patients with coronary heart disease after intervention

Objective:To observe the efficacy and safety of high-dose Atorvastatin in patients with coronary heart disease after intervention. Methods:74 patients after successful coronary intervention were randomly divided into two groups,based on the conventional therapy the treatment group with Atorvastatin 80 mg/d and the control group with Atorvastatin 20 mg/d,the ischemic event,blood lipids and high sensitivity C reactive protein(hs-CRP) ,and adverse reactions of two groups were observed after 3 months. Results:The incidence of cardiac ischemic events in treatment group was lower than the control group,there was significant difference(P0.05) .Lipids and C-reactive protein levels decreased in treatment group was better than the control group,there was significant difference(P0.05) . Medication groups after 1 month [treatment group(6 cases) ,control group(4 cases) ] had slightly elevated alanine aminotransferase,there was no significant difference between the two groups(P0.05) . Conclusion:High-dose Atorvastatin therapy in patients after coronary intervention has notable curative effect and no serious side effects.