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Research of expression and significance of YKL-40 in articular cartilage of osteoarthritis

Yangkan Ou

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Abstract

[Objective] To investigate the expression and significance of YKL-40 in articular cartilage of osteoarthritis. [Methods] Immunohistochemistry and TUNEL assay were used to detect the expression of YKL-40 proteins in articular cartilage and the apoptosis of the articular chondrocytes cell in 22 cases. [Results] The positive expression rate of YKL-40 protein in osteoarthritic chondrocytes was higher than that in normal chondrocytes(P 0.05). [Conclusion] There was a consanguineous correlation between degrees of the expression of YKL-40 and chondrocytes apoptosis in osteoarthritic articular cartilage.

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What this paper is about

[Objective] To investigate the expression and significance of YKL-40 in articular cartilage of osteoarthritis. [Methods] Immunohistochemistry and TUNEL assay were used to detect the expression of YKL-40 proteins in articular cartilage and the apoptosis of the articular chondrocytes cell in 22 cases. [Results] The positive expression rate of YKL-40 protein in osteoarthritic chondrocytes was higher than that in normal chondrocytes(P 0.05). [Conclusion] There was a consanguineous correlation between degrees of the expression of YKL-40 and chondrocytes apoptosis in osteoarthritic articular cartilage.

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Available abstract

[Objective] To investigate the expression and significance of YKL-40 in articular cartilage of osteoarthritis. [Methods] Immunohistochemistry and TUNEL assay were used to detect the expression of YKL-40 proteins in articular cartilage and the apoptosis of the articular chondrocytes cell in 22 cases. [Results] The positive expression rate of YKL-40 protein in osteoarthritic chondrocytes was higher than that in normal chondrocytes(P 0.05). [Conclusion] There was a consanguineous correlation between degrees of the expression of YKL-40 and chondrocytes apoptosis in osteoarthritic articular cartilage.

Key concepts: Osteoarthritis, Articular cartilage, Cartilage, TUNEL assay, Immunohistochemistry, Apoptosis, Chondrocyte, Medicine

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