2005•Chinese Journal of PharmaceuticsRequires access
The study of in vitro release of roxithromycin from sustainedreleased pellets
Tong Ji
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Abstract
objective To evaluate the in vitro release of roxithromycin from sustained-released pellets.Methods In vitro release was evaluated by the method for release determination described in the Ch.P.2000 Ed. Result Amount of lactose in coating material,the coating thickness,etc,had significantly effects on the release rate. The profiles of sustained-release were obtained at the following condition: Eudragit NE30D as the coating material,coating temperature of 21～28 ℃,amount of lactose was 100 g·L-1in coating material,increased weight on the pellets by coating material was 50g·L-1. Conclusion The prepared pellets met the release standard of 24 h sustained release formulation.