Preparation and in vitro release of ketoprofen sustained-release pellets

Objective To prepare ketoprofen sustained-release pellets and study their in vitro release characteristics. Methods Pellets were prepared by centrifugal-coating granulation method,using Eudragit NE30D and EudragitL30D-55 mixture as sustained-release coating materials. Factors influencing the release rate of ketoprofen from the sustained-release pellets were studied. Results The coated pellets showed an excellent roundness and the yield was over 90%. The release rate of ketoprofen was mainly affected by the coating level and the ratio of EudragitNE30D and EudragitL30D-55,and it increased with the raise of the medium pH. Conclusions Ketoprofen sustained–release pellets were successfully prepared. The in vitro drug release profile followed first order kinetics.