PCNA expression and its clinical significance in pituitary adenoma

Objective: To study the appearance and clinical significance of proliferating cell nuclear antigen(PCNA) in pituitary adenoma. Methods: The expression levels of PCNA pathological paraffin specimens were detected in 25 cases of invasive pituitary adenomas,22 cases of noninvasive pituitary adenomas and 4 cases of normal human pituitary tissues by immunohistochemical SP methods. The correlation between PCNA and recrudescence of the invasive pituitary adenoma was analysed in statistics. Results: The expression of PCNA was significantly higher in invasive pituitary adenomas than that in noninvasive pituitary adenomas(P0.05); The expression of PCNA was significantly higher in the recurrent group than that in nonrecurrent group in invasive pituitary adenomas(P0.05). Conclusion: The abnormal expression of PCNA may be valuable in the proliferation of adenoma cells and invasive potential in pituitary adenomas tissues, which can be taken as indicators to evaluate the tumor invasive activity,recurrence,treatment and prognosis in clinic.