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2008•Chinese Journal of Drug Application and MonitoringRequires access

Analysis of 1933 ADR reports in PLA General Hospital

Guiyang Liu

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Abstract

Objective:To investigate the essential features of adverse drug reaction(ADR) which take place in our hospital, avoid risk of clinical drug use, and control the present situation of ADR monitoring.Methods:ADR reports in 2004~2006 were downloaded from provincial center for ADR monitoring interms of Excel form.Some dataformats were coverted or added necessarily.All items of the report form were collected and analyzed.Results:The anti-infective agents, antineoplastic agents and TCM ranked first, second and third among 1933 ADR reports.The lesions of ADR involved body as a whole-general disorders, then gastrointestinal system.1601 (82.8%) ADR reports were included by the intravenous route of administration.10 categories drugs and total 68 kinds of medicines were involved in 116 new and severe ADR reports.Conclusion:The multiple factors lead to the high frequency of ADR cases, especially drug use frequency.It is essential to analyze the new and severe ADR reports, extract signal, expand safe research, announce pharmacovigilance, reduce to a lower rank of drug use.

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Objective:To investigate the essential features of adverse drug reaction(ADR) which take place in our hospital, avoid risk of clinical drug use, and control the present situation of ADR monitoring.Methods:ADR reports in 2004~2006 were downloaded from provincial center for ADR monitoring interms of Excel form.Some dataformats were coverted or added necessarily.All items of the report form were collected and analyzed.Results:The anti-infective agents, antineoplastic agents and TCM ranked first, second and third among 1933 ADR reports.The lesions of ADR involved body as a whole-general disorders, then gastrointestinal system.1601 (82.8%) ADR reports were included by the intravenous route of administration.10 categories drugs and total 68 kinds of medicines were involved in 116 new and severe ADR reports.Conclusion:The multiple factors lead to the high frequency of ADR cases, especially drug use frequency.It is essential to analyze the new and severe ADR reports, extract signal, expand safe research, announce pharmacovigilance, reduce to a lower rank of drug use.

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Available abstract

Objective:To investigate the essential features of adverse drug reaction(ADR) which take place in our hospital, avoid risk of clinical drug use, and control the present situation of ADR monitoring.Methods:ADR reports in 2004~2006 were downloaded from provincial center for ADR monitoring interms of Excel form.Some dataformats were coverted or added necessarily.All items of the report form were collected and analyzed.Results:The anti-infective agents, antineoplastic agents and TCM ranked first, second and third among 1933 ADR reports.The lesions of ADR involved body as a whole-general disorders, then gastrointestinal system.1601 (82.8%) ADR reports were included by the intravenous route of administration.10 categories drugs and total 68 kinds of medicines were involved in 116 new and severe ADR reports.Conclusion:The multiple factors lead to the high frequency of ADR cases, especially drug use frequency.It is essential to analyze the new and severe ADR reports, extract signal, expand safe research, announce pharmacovigilance, reduce to a lower rank of drug use.

Key concepts: Medicine, Pharmacovigilance, Drug reaction, Drug, Adverse drug reaction, Pharmacology, Intensive care medicine

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