Effect and safe experiment of Pour-sprinkling preparation of Ivermectin for deworming nematode of sheep

The pour-sprinkling preparation of 0.5% Ivermectin in a dose of 0.3,0.4 and 0.5mg/kg.were given to sheep by means of single pour-sprinkling the skin along center line on bodyback of sheep.Ivermectin in a dose of 0.2mg/kg.was injected as control.The results showed that negative rate of nematode ova of alimentary canal in the sheep of 0.3mg/kg.and 0.4mg/kg.groups were 85% and 90%,and the reductive rate were 89.1% and 95.9%,respectively.The negative rate of protstrongylus larvae were 60% and 75%,and the reductive rate were 77.2% and 86.7%,respectively.The both negative rate and reductive rate of nematode ova of alimentary canal in the sheep of 0.5mg/kg.group were 100%,and the negative rate and reductive rate of protstrongylus larvae in dose 0.5mg/kg.were 85% and 95.4%,respectively.The results of amatomical examination showed that the three dose of Ivermectin pour-sprikling preparation had good effect for many nematodes in alimentary canal and breath canal of sheep,The total deworming were rate 90.8%,95.6% and 99.7%,respectively.The deworming effect dose 0.5mg/kg.of Ivermectin pour-sprikling preparation and 0.2mg/kg.injection was same.Shep can bear 1.0mg/kg.dose which given by skin,The experiment proved that Ivermectin pour-sprikling preparation was effective and safe for deworming nematode by means of giving medicine through skin.The clinical recommendation dosage.was 0.5mg/kg.