Expression of VEGF in non -small cell lung cancer and its correlation with pathological characteristics

Objective:To investigate the expression of VEGF in non -small cell lung cancer and its correlation with pathological characteristics.Methods:All 72 cases of lung cancer tissues 72 cases of lung cancer adjacent tissues and 30 cases of benign lesions were detected by immunohistochemistry.The expression of VEGF was detected by im-munohistochemistry.The correlation between VEGF expression and clinical pathological features and prognosis were compared.Results:The positive expression rate of VEGF in non -small cell lung cancer tissues was 73.61%, 45.83% in the adjacent tissues,and 26.67% in benign lesions,the difference was statistically significant(P<0.05). VEGF expression was associated with pathological type,lymph node metastasis,TNMstage,tumor size and differentia-tion degree in non -small cell lung cancer(P <0.05).VEGF positive expression and VEGF negative expression in the survival of patients,the difference was statistically significant(P <0.05).Conclusion:VEGF protein is highly ex-pressed in non -small cell lung cancer tissues,and its expression is closely related to the occurrence and development of tumor.The prognosis of patients with VEGF protein expression is worse,which can be used as a reference index for the prognosis of patients with non -small cell lung cancer.