Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance

Objective:Toinvestigate the role ofmaspin,p53 and Skp2 expression in the progression ofcolorectal tumors,and tounderstand their clinicopathological significance.Methods:The expression of maspin,p53 and Skp2 in colorectal adenocarcinoma(n=50),adenoma(n=20)and normal tissue(n=20)were detected by immunohistochemistry and compared with the clinicopathological tumor parameters.The relationship among the expression of maspin,p53,and Skp2 was also analyzed in colorectal tumors.Results:Maspin expression was much lower in colorectal adenocarcinoma than in adenoma and normal tissues(P0.05).Maspin expression showed a negative association with lymphatic metastasis and higher Dukes stage(P0.05).Expression of maspin protein was negatively correlated with p53 expression(P0.01).However,there was no significant correlation between expression of Skp2 and p53 or maspin(P0.05).Conclusion:Maspin might be regulated by the p53 pathway.Combined detection of the expression of maspin,p53,and skp2 may be useful for evaluating its infiltration,metastasis and prognosis.