Significance of maspin expression in colorectal cancer

Objective To investigate maspin expression in colorectal carcinoma and it's role in tumorgenesis, progression and metastasis of colorectal carcinoma, and assess the relationship between maspin expression and prognosis of colorectal carcinoma. Methods Maspin expression in colorectal carcinoma, colorectal polypous adenoma tissues, normal colorectal tissue, lymph node metastasis and liver metastasis was investigated by PV immunohistochemical assay. Data of maspin expression in each tissue was analyzed using statistical methods. Results Maspin expression showed a significant decrease from normal coloreetal tissue to adenoma and adenocarcinoma. Maspin expression in colorectal carcinoma with liver metastasis was lower than that without liver metastasis (P0.05). Maspin expression in different pathological type was down-regulated with the increasing of malignant degree (P0.05). The patients with maspin expression survive longer than those without maspin expression. Conclusions Down regulation of maspin expression plays an important role in tumorgenesis, progression and metastasis of colorectal carcinoma. Maspin expression will be a prediction index for liver metastasis of coloreetal carcinoma and a index for prognosis analysis of patients with colorectal carcinoma.