Relationship between serum adopinectin levels and the carotid plaque in patients with acute cerebral infraction

Objectives To explore the relationship between stability of carotid plaque and serum adopinectin(APN) in patients with acute cerebral infarction(ACI).Methods 113 patients with initial acute cerebral infarction and 31 healthy persons were checked by using carotid ultrasonographic methods.Patients were divided into three groups:no carotid plaques(NCP,n= 39),stable plaques(SP,n = 34),vulnerable plaques(VP,n = 40).The serum concentration of APN was measured by means of ELISA.Results The serum level of APN was significantly lower in the patients with ACI than that in the healthy controls(P0.01).Incidence of carotid artery athermatosis, plaque and stenosis were higher than healthy controls(P0.05).The serum level of APN was significantly lower in VP than that in NCP,SP and the healthy controls(P0.05);the serum level of APN was significantly lower in SP than that in NCP and the healthy controls(P0.05); the serum level of APN was significantly lower in NCP than that in the healthy controls(P 0.05).The serum APN levels in the patients at day 14 after suffering from ACI were more than that in the patients within 48 hours after the suffering from ACI(P0.05).Conclusions The decrease of serum APN levels significantly correlated with the existence and character of carotid plaque in patients with ACI.