Analysis of Drug Resistance and β-Lactamases in Acinetobacter baumannii

Objective To investigate the drug resistance and β-lactamases in clinical isolates Acinetobacter baumannii in the Third Hospital of Changsha. Methods The drug sensitivity was performed by K-B method. The ESBLs enzyme and AmpC enzyme were detected by phenotypic confirmatory test and phenotypic screening method,respectively. Results The resistance rates of 86 strains of Acinetobacter baumannii to ampicillin/sulbactam,cefoperazone/sulbactam,imipenem and meropenem were 25.6%,9.2%,17.4% and 15.1%,respectively,but to other 10 kinds of antibiotics were higher (39.5%～67.4%). 21 strains (24.4%) were found to produce ESBLs and 31 strains (36.0%) were found to produce AmpC enzyme. Conclusions The drug resistant rate of Acinetobacter baumannii is high in the Third Hospital of Changsha,so drug susceptibility test should be enforced to guide clinicians applying antibiotics reasonably; its resistance to β-lactam drug is related to ESBLs and AmpC enzymes.