Clinical analysis of detection of immunoglobulin and Th1/Th2 in children with recurrent respiratory tract Infection.

【Objective】 To investigate the clinical significance of detection of immunoglobulin and Th1/Th2 in children with recurrent respiratory tract infection(RRI). 【Methods】 Levels of IgG,IgA,IgM,IL-4 and IFN-γ in peripheral blood were measured in 30 cases of children with RRI before and after treatment,and compared with those in the control group. 【Results】 Before treatment,the levels of IgG,IgA and IgM in RRI group were lower than those of the control group respectively(P0.05).The content of IL-4 was significantly higher than that of the control group(P0.01),while IFN-γ was significantly lower(P0.01).After treatment,the levels of IgG,IgA and IgM in RRI group were increased significantly(P0.05),IL-4 apparently decreased(P0.01) and IFN-γ increased significantly(P0.01). 【Conclusion】 The depression of humoral immunofunction and maladjustment of cellular immunofunction were observed in children with RRI.Clinically,detection of the levels of IgG,IgA,IgM,IL-4 and IFN-γ in the peripheral blood from children with RRI could be taken as a predictive marker for disease severity and reference marker for therapy termination.