TRIMETAZIDINE COMBINED WITH ROUTINE TREATMENT THERAPY FOR INSTABILITY ANGINA PECTORIS

Objective: To investigate the therapeutic effects of Trimetazidine combined with usual therapy for instability angina pectoris. Methods: 52 cases of the patients with instability angina pectoris were randomly divided into two groups: routine treatment group (n=26) and combined treatment group (n=26). βreceptor blocker, nitrates, Ca2+ blocker, the inhibitor of angiotensin transferase, and anti-platelet drug were used in the routine treatment group and Trimetazidine combined with routine therapy in combined treatment group for 4 weeks. The changes of symptoms and dynamic ECG of the patients from the two groups were observed. Results: The combined treatment group showed much better curative effects than routine group in all indices of ischemia attack times, decreasing amplitude of S-T segment, reducing total ischemia time (P 0.01). Conclusion: Trimetazidine combined with routine therapy are much effective and much safe for instability angina pectoris.