A Clinical Study of the Efficacy of Quetiapine Combined with Paroxetine in the Treatment of Obsession

Objective:To evaluate the clinical efficiency and safety of quetiapine combined with paroxetine in treating obsession.Methods:47 patients with obsession were randomly divided into paroxetine group and quetiapine with paroxetine group,and then follow up for 8 weeks.Yale-Brown Obsessive-compulsive disorder scale(Y-BOCS),Hamilton anxiety scale(HAMA)and treatment emergent symptom scale(TESS)were used to evaluate the efficiency and adverse effects.Results:The scores of Y-BOCS and HAMA at the base time were Similarly.Yet the Y-BOCS score of the quetiapine with paroxetine group(12.4±4.7)was lower than it of the paroxetine group(16.1 ±3.9,t=2.576,P=0.03).The HAMA score of the quetiapine with paroxetine group(6.9±3.8)was lower than the it of the paroxetine group(10.1±3.6,t=2.236,P=0.017).Conclusion:Quetiapine combined with paroxetine have exacta efficiency and safety in treating Obsession.