2011•Journal of Apoplexy and Nervous DiseasesRequires access
Gene-gene interaction between LPL and PON1 gene with cerebral infarction
DU Dan-hua
Open publisher page 0 citations
Abstract
Objective To investigate the gene-gene interaction between LPL and PON1 gene with cerebral infarction.Methods A case-control study was performed within 705 acute ischemic stroke patients and 431 controls.LPL gene rs328,rs326,PON1 gene rs2299262,rs854552,rs662 genotypes were determined by PCR-RFLP.Results Allelic frequencies of rs328 at LPL locus showed significant difference between arteriosclerotic thrombotic cerebral infarction and control groups.Odds radio(OR) was 1.47(χ2=4.83,P=0.034,OR=1.47,95%CI=1.03~2.13).Allelic frequencies of rs326 and at LPL locus showed significant difference between arteriosclerotic thrombotic cerebral infarction and control groups.Odds radio(OR) was 1.64(χ2=3.597,P=0.047,OR=1.64,95%CI=1.12~1.84).rs229262 on PON1 gene and rs328 on LPL gene had synergy on ischemic stroke(χ2=6.26,df=2,P=0.043).Conclusion rs229262 on PON1 gene and rs328 on LPL gene have synergy on ischemic stroke.