Effect of mosapride citrate on functional dyspepsia

Objective: To investigate the effect of mosapride citrate on functional dyspepsia (FD). Methods: Sixty pa-tients with FD were randomized into 2 groups. Five mg mosapride citrate was given 3 times daily to the medical group, and 5mg cisapride 3 times daily to the control group for 4 weeks. At the end of the medication, gastric emptying of solid food withradiopaque markers was carried out in patients with delayed gastric emptying at the beginning. Results: Both mosapride andcisapride significantly improved the symptoms of early satiety, abdominal distention, abdominal pain, belching, regurgitationand heartburn in patients with FD (P＜0. 01). The effective rate of mosapride on the above symptoms were 59. 09%,55. 56%, 81. 82%, 71. 43%, 100% and 76. 92% respectively, which had no significant difference to that of cisapride(45. 45%, 73. 33%, 71. 43%, 82. 61%, 92. 86% and 66. 67%, respectively). Besides, mosapride and cisapride improvedgastric emptying rate in patients with delayed gastric emptying,the effective rate were 88. 24% and 83.33%, respectively.There were no side effects or prolongation of QTC intervals in 2 groups. Conclusion: Mosapride citrate is an effective andsafe medicine in the treatment of FD.