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2004•Linchuang pifuke zazhiRequires access

Effects of leflunmide on secretion of TNF-α, IL-6 and IL-8 in HaCaT cell

Qing-Sheng Mi

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Abstract

Objective: To observe the effects of leflunomide on the secretion of TNF-α,IL-6 and IL-8 in HaCaT cell. Methods: HaCaT cell was cultured in vitro, and treated with different concentrations of leflunmide. Concentrations of IL-6 and IL-8 were determined by ELISA. Results: spontaneously. After treatment with leflunmide, the secretion levels of TNF-α, IL-6 and IL-8 decreased. The levels of IL-6 and IL-8 increased after induction of TNF-α, and decreased after leflunmide treatment. Conclusions: Leflunmide can inhibit the secretion of TNF-α,IL-6 and IL-8 in HaCaT cell.

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What this paper is about

Objective: To observe the effects of leflunomide on the secretion of TNF-α,IL-6 and IL-8 in HaCaT cell. Methods: HaCaT cell was cultured in vitro, and treated with different concentrations of leflunmide. Concentrations of IL-6 and IL-8 were determined by ELISA. Results: spontaneously. After treatment with leflunmide, the secretion levels of TNF-α, IL-6 and IL-8 decreased. The levels of IL-6 and IL-8 increased after induction of TNF-α, and decreased after leflunmide treatment. Conclusions: Leflunmide can inhibit the secretion of TNF-α,IL-6 and IL-8 in HaCaT cell.

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Available abstract

Objective: To observe the effects of leflunomide on the secretion of TNF-α,IL-6 and IL-8 in HaCaT cell. Methods: HaCaT cell was cultured in vitro, and treated with different concentrations of leflunmide. Concentrations of IL-6 and IL-8 were determined by ELISA. Results: spontaneously. After treatment with leflunmide, the secretion levels of TNF-α, IL-6 and IL-8 decreased. The levels of IL-6 and IL-8 increased after induction of TNF-α, and decreased after leflunmide treatment. Conclusions: Leflunmide can inhibit the secretion of TNF-α,IL-6 and IL-8 in HaCaT cell.

Key concepts: HaCaT, Secretion, Tumor necrosis factor alpha, Interleukin, Chemistry, Cell, In vitro, Endocrinology

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Effects of leflunmide on secretion of TNF-α, IL-6 and IL-8 in HaCaT cell — Research Paper | ScholarLens