Effects of Two Kinds of Terpenes on Percutaneous Penetration of Metronidazole on Skin in Vitro

ObjectiveTo compare the permeation enhancing effect of azone,synthetic borneol and menthol and to provide theoretic foundation for finding more reasonable and effective penetration enhancers.MethodsThe transdermal absorption test and the research of deposit function on penetration experiment apparatus.ResultsWhen azone,synthetic borneol and menthol were used separately,they had notable transdermal permeation enhancing effect of metronidaze.The enhansive permeation multiple was 2.48,2.19and 2.66;while penetrateion enhancing effect was strengthen greatly when azone was used with synthetic borneol or menthol(P0.01).Deposit function had little influence on transdermal absorption enhancing effect of metronidazole when azone was used separately,but when azone was used with synthetic borneol or menthol,deposit function was reinforced greatly.ConclusionSynthetic borneol and menthol had notable transdermal permeation enhancing effect of metronidazole,and when they are used with azone,the enhancing function is more notable.