The clinical value of pleural fluid measuring and serum CEA,CA153,CA125,CA199 measuring in the diagnosis of pleural effusion

Objective To explore the value of CEA,CA153,CA125,CA199 detection in pleural fluid and serum in the diagnosis of pleural effusion. Method Use Immunohistochemical electrochemiluminescence to detected CEA,CA153,CA125,CA199 concentration in pleural fluid and serum of 64 cases of pleural effusion; draw ROC curve to determine the malignant optimal threshold in the diagnosis of pleural effusion,parallel test and sequence analysis of single or joint detection test for four tumor markers. Findings Four tumor markers in pleural effusion,serum of malignant were higher than in the benign group( P 0. 05 or P 0. 01); CEA,CA153,CA199 single detection of benign and malignant differential diagnosis with high specificity,sensitivity deviation,CA125 single detection opposite; to single detection threshold is standard,pleural effusion,the sensitivity of serum tumor markers in four joint detection,specificity,Youden index were higher than the detection of individual indicators. Conclusion Pleural fluid and serum CEA,CA153,CA125,CA199 combined detection can play a complementary role in a good diagnosis and differential diagnosis of pleural effusion,and pleural effusion or serum than just detect these indicators diagnostic sensitivity,high specificity.