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Diagnostic value of combination measurement of tumor markers for differentiating malignant and pleural effusion

Jian Yu

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Abstract

[Objective] To study the diagnostic value of determining carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9) and carbohydrate 12-5(CA12-5) in the serum and pleural effusion in the differential diagnosis of benign and malignant pleural effusions.[Methods] The levels of tumor markers of CEA,CA19-9 and CA12-5 in serum and pleural effusion were measured in 179 patients with malignant pleural effusion and 167 patients with benign pleural effusion by ELISA method.The best diagnostic cut-off and the sensitivity,specificity and accuracy of them were analyzed.[Results] If the cut-off of serum CEA was ≥ 3.90 ng/mL,the sensitivity,specificity and accuracy of diagnosing malignant pleural effusion were 59.78%,64.07% and 62.85% respectively.If the cut-off of pleural effusion CEA was ≥ 2.25 ng/mL,the sensitivity,specificity and accuracy of diagnosing malignant pleural effusion were 65.36%,72.45% and

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[Objective] To study the diagnostic value of determining carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9) and carbohydrate 12-5(CA12-5) in the serum and pleural effusion in the differential diagnosis of benign and malignant pleural effusions.[Methods] The levels of tumor markers of CEA,CA19-9 and CA12-5 in serum and pleural effusion were measured in 179 patients with malignant pleural effusion and 167 patients with benign pleural effusion by ELISA method.The best diagnostic cut-off and the sensitivity,specificity and accuracy of them were analyzed.[Results] If the cut-off of serum CEA was ≥ 3.90 ng/mL,the sensitivity,specificity and accuracy of diagnosing malignant pleural effusion were 59.78%,64.07% and 62.85% respectively.If the cut-off of pleural effusion CEA was ≥ 2.25 ng/mL,the sensitivity,specificity and accuracy of diagnosing malignant pleural effusion were 65.36%,72.45% and

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Available abstract

[Objective] To study the diagnostic value of determining carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9) and carbohydrate 12-5(CA12-5) in the serum and pleural effusion in the differential diagnosis of benign and malignant pleural effusions.[Methods] The levels of tumor markers of CEA,CA19-9 and CA12-5 in serum and pleural effusion were measured in 179 patients with malignant pleural effusion and 167 patients with benign pleural effusion by ELISA method.The best diagnostic cut-off and the sensitivity,specificity and accuracy of them were analyzed.[Results] If the cut-off of serum CEA was ≥ 3.90 ng/mL,the sensitivity,specificity and accuracy of diagnosing malignant pleural effusion were 59.78%,64.07% and 62.85% respectively.If the cut-off of pleural effusion CEA was ≥ 2.25 ng/mL,the sensitivity,specificity and accuracy of diagnosing malignant pleural effusion were 65.36%,72.45% and

Key concepts: Carcinoembryonic antigen, Medicine, Malignant pleural effusion, Pleural effusion, Differential diagnosis, Diagnostic accuracy, Effusion, Tumor marker

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