Analysis to the sequential mechanical ventilation in acute organophosphate poisoning with intermediate syndrome

To evaluate the possibility and the clinical value of the sequential mechanical ventilation in acute organophosphate pesticides poisoning(AOPP)with intermediate syndrome.Methods One hundred patients with intermediate syndrome were included in the study.Of them,50 were randomly allocated to receive sequential mechanical ventilation,and the other 50 received invasive positive pressure ventilation(IPPV).And ventilator-associated pneumonia(VAP),mechanical ventilation duration,weaning failure,the length of hospitalization was measured.Results There were significant differences in invasive ventilation time,the total duration of mechanical ventilation,venti1ator-associated pneumonia(VAP),weaning failure,the length of hospitalization and mortality between the sequential treatment group and the control group(P0.05).Condusion Invasive-noninvasive ventilation is effective in the treatment of AOPP cases with intermediate syndrome,it can significantly shorten the time of invasive ventilation,the length of hospitalization and reduce the incidence of VAP,weaning failure.