Observation of the clinical efficacy of LFTP regimen in the treatment of 96 advanced colorectal cancer patients

Objective To evaluate the clinical efficacy and the toxicity of the combination chemotherapy(LFTP regimen) with pirarubicin(THP),fluorouracil(5-Fu),leucovorin(LV) and cisplatin(DDP) in the treatment of advanced colorectal cancer.Methods Ninety-six patients with advanced colorectal cancer were treated with LFTP regimen.THP was given iv gtt on the first day at a dose of 35 mg/m2,DDP was given iv gtt on the days 1-5 at a dose of 20 mg/m2,LV was given iv gtt on days 1-5 at a dose of 200 mg/m2 and 5-Fu was given at a dose of 500 mg/m2 on the days 1-5 by intravenous drip for 6 hours each day.The chemotherapy was repeated every 21 days and a course of treatment included three cycles.Results Seven patients showed complete response(7.6%),36 partial response(39.1%) and 20 had progression of disease(21.8%).The total effective rate was 46.7%.The main toxic effects were myelosuppression and stomatitis.There was no chemotherapy-related death.Conclusion LFTP regimen is effective and well tolerated in the treatment of advanced colorectal cancer.Therefore,it has significance for clinical therapy.