2010•Qilu Pharmaceutical AffairsRequires access

Determination of ropisentron hydrochloride in Tropisentron Hydrochloride and Sodium Chloride Injection by HPLC

Chang Ming Li

Abstract

OBJECTIVE The content determination of ropisentron hydrochloride in tropisentron Hydrochloride and sodium chloride injection by RP-HPLC.METHODS Column was used with octadecyl silane boned silica gel as filler.The mobile phase was Methanol-water-acetonitrile-triethylamine(62∶26∶12∶0.2).The detection wavelength was 284nm.RESULTS Ropisentron hydrochloride showed a good linear relationship in the range of 2～40μg·mL-1(Y=15.623X+8.16,r=0.9997)and the average recovery was 99.72%,RSD was 0.63%.CONCLUSION The method was simple,sensitive,accurate,and good accuracy.It can be used for the determination of ropisentron hydrochloride.

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Key concepts: Chromatography, Chemistry, Triethylamine, High-performance liquid chromatography, Hydrochloride, Sodium, Silica gel, Content determination