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2010•Zhongguo yiyuan yongyao pingjia yu fenxiRequires access

Monitoring Results of Serum Concentration of Sodium Valproate: Analysis of 30 Epileptic Patients

DU Yan-qi

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Abstract

OBJECTIVE: To analyze serum concentriaton of sodium valproate in epileptic patients so as to guide clinical rational drug use. METHODS: Serum concentrations of sodium valproate in 30 epileptic cases were determined by fluorescence polarization immunoassay and the results were analyzed. RESULTS: Of the total 30 cases monitored, serum concentrations of sodium valproate in 6 cases (20. 00% ) were less than 50 μg·mL-1 with an effective rate of 16. 67% ,in 23 (76. 67% ) were within 50 ～ 100 μg·mL-1with an effective rate of 73. 91% and in 1 (3. 33% ) was greater than 100 μg·mL-1with an effective rate of 100. 00% . CONCLUSION: There are great individual differences with regard to serum concentration of sodium valproate in in epileptic patients. Timely monitoring of serum concentration of sodium valproatein and individualized therapy are preferable.

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OBJECTIVE: To analyze serum concentriaton of sodium valproate in epileptic patients so as to guide clinical rational drug use. METHODS: Serum concentrations of sodium valproate in 30 epileptic cases were determined by fluorescence polarization immunoassay and the results were analyzed. RESULTS: Of the total 30 cases monitored, serum concentrations of sodium valproate in 6 cases (20. 00% ) were less than 50 μg·mL-1 with an effective rate of 16. 67% ,in 23 (76. 67% ) were within 50 ～ 100 μg·mL-1with an effective rate of 73. 91% and in 1 (3. 33% ) was greater than 100 μg·mL-1with an effective rate of 100. 00% . CONCLUSION: There are great individual differences with regard to serum concentration of sodium valproate in in epileptic patients. Timely monitoring of serum concentration of sodium valproatein and individualized therapy are preferable.

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Available abstract

OBJECTIVE: To analyze serum concentriaton of sodium valproate in epileptic patients so as to guide clinical rational drug use. METHODS: Serum concentrations of sodium valproate in 30 epileptic cases were determined by fluorescence polarization immunoassay and the results were analyzed. RESULTS: Of the total 30 cases monitored, serum concentrations of sodium valproate in 6 cases (20. 00% ) were less than 50 μg·mL-1 with an effective rate of 16. 67% ,in 23 (76. 67% ) were within 50 ～ 100 μg·mL-1with an effective rate of 73. 91% and in 1 (3. 33% ) was greater than 100 μg·mL-1with an effective rate of 100. 00% . CONCLUSION: There are great individual differences with regard to serum concentration of sodium valproate in in epileptic patients. Timely monitoring of serum concentration of sodium valproatein and individualized therapy are preferable.

Key concepts: Sodium, Serum concentration, Fluorescence polarization immunoassay, Epilepsy, Carbamazepine, Medicine, Valproic Acid, Plasma concentration

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