Correlation between prehypertension and serum hsCRP and IL-6 in Xinjiang kazakh population

Objective To explore the relationship between prehypertension and hsCRP and IL-6 in xinjiang kazakhs population and its clinical signifcance. Methods A total of 396 kazahs from physical-examination in 2011 were chosen and divided into the normal group( n = 124),prehypertension group( n = 144) and hypertension group( n =128). The levels of serum hsCRP,IL-6,total cholesterol( TC),triglyceride( TG),high-density lipoprotein cholesterol( HDL-C),low-density lipoprotein cholesterol( LDL-C),and fasting plasma glucose( FBG) were detected in all the participants. Results There were significant difference in the levels of serum TC,TG,LDL-C,HDL-C,FBG, systolic blood pressure( SBP) and diastolic blood pressure( DBP) among three groups( all P 0. 01). The levels of serum hsCRP and IL-6 were higher in the prehypertension group than those in the normal group( P 0. 01),and lower than those in the hypertension group( P 0. 01). The result of multiple linear stepwise regression showed that hsCRP and IL-6 were correlated to SBP and DBP independently( P 0. 001). Conclusion The people with prehypertension have higher levels of serum hsCRP and IL-6 in xinjiang kazakhs population,which may be involved in the development of prehypertension.